The research in our lab covers a wide range of areas in biomedical optics and nanobiotechnology, with special emphasis on the development of cutting-edge ultrasensitive and ultrafast laser-based detection techniques and methodologies to address critical issues at the frontier of biomedical research and applications, including cancer research, drug delivery, drug toxicity assays, and neuroscience. We welcome highly motivated and talented students, postdocs, visiting scholars to join our lab and work together on different exciting research projects. If interested, please contact Dr. Ye to inquire the possibilities.
Controlled Drug Delivery
Drug Toxicity Assays and Pharmaceutical Quality Control
We are grateful for the following funding agencies for their grant support of our research projects.
National Institutes of Health (NIH), including NCI, NIBIB, and NIGMS
United States Department of Defense (DoD)
National Science Foundation (NSF)
Cancer Prevention Research Institute of Texas (CPRIT)
United States Department of Agriculture (USDA)
San Antonio Area Foundation
San Antonio Life Sciences Institute
UTSA-SwRi Connect Grant
UTSA VPR Office
Harry S Moss Heart Trust
Collaboration is crucial to success. We encourage collaborations and would be happy to share the following instruments for joint projects.
1) A state-of-the-art photoacoustic tomography system: MSOT (Multispectral Optoacoustic Tomography) inVision 256-TF small animal in vivo imaging system from iThera Medical, Inc.
For general users (without collaboration), please contact us to arrange the time for your imaging experiments. The cost is $150 per hour for using the system.
For collaborative projects, please contact us for detailed arrangements.
Acknowledgement to the grant support from DoD W911NF-17-1-0488
2) An optoacoustic imaging system LOIS-2D from TomoWave Laboratories, Inc.
3) A supercontinuum generation system pumped with a picosecond fiber laser (SC400-PP, Fianium).
This is an ultra-broadband supercontinuum radiation source with a built in pulse-picker to control repetition rate.
4) A time-correlated single-photon counting system (SPC 130, Becker & Hickl).
This system has picosecond resolution, ultra-high sensitivity, high-speed on-board data acquisition, and multi-detector / multi-wavelength capability.
5) An OPO system pumped with a Q-switched Nd:YAG laser (Surelite OPO Plus pumped with SLIII, Continuum).
Tunability from 410-2650nm is achieved with the THG (355nm) of a Q-switched Nd:YAG laser. This system provides high pulse energy (up to 70mJ) and 3-5 ns pulse duration.
6) A 300-MHz ultrasound pulser/receiver (DPR500-H02-H02, JSR/Imaginant) and a 150 MHz ultrasound transducer.
This system has two complete high frequency ultrasound pulser/receivers integrated into one unit. The bandwidth of the receiver and the bandwidth of the pulser are both larger than 300 MHz.
7) A Swept laser source from Axsun for Optical Coherence Tomography.
High Speed (50kHz) Sweep Rate, High Output Power (20mW Average), Wide (>100nm) Tuning Range.
8) A surface plasmon resonance based label-free bioassay system (Biacore 2000)
9) A high precision spin coating system with a spin speed up to 10,000rpm.
10) Photon-counting photomultiplier tubes for sensitive fluorescence detection.
Department of Biomedical Engineering
The University of Texas at San Antonio
One UTSA Circle
San Antonio, TX 78249-0670
Phone: (210) 458-5056